Santa Fe vs Deportivo Cali Predictions: Odds and betting tips for Primera A 2025 Match - 10.11.2025

On November 10, 2025, at 03:30 CEST, the storied Estadio Nemesio Camacho El Campin in Bogotá will serve as the battleground for Santa Fe and Deportivo Cali in Colombia’s Primera A Clausura phase. This fixture brings together two historic sides eager to assert themselves as the domestic campaign reaches its decisive stretch. For Santa Fe, currently 10th, this is a crucial moment to reignite their top-eight aspirations, while Deportivo Cali, sitting 14th, must halt their worrying winless spiral to avoid being further adrift.

All eyes will rest on Santa Fe’s dynamic forward, Hugo Rodallega, whose recent finishing—including a brace in recent matches—makes him the main attacking weapon for the hosts. Meanwhile, Deportivo Cali’s Andrey Estupiñán stands out for his key goalscoring contributions amid his team’s struggles, offering a consistent threat that could upset the balance.

A standout statistic heading into this clash: Deportivo Cali are yet to secure a win in their last four matches, underlining major defensive and creative frailties.

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Santa Fe vs Deportivo Cali predictions

My best bet: Santa Fe to win. Driven by home advantage at El Campin and superior recent form (one win, two draws from last five), Francisco López’s side approaches the fixture with a mixture of urgency and confidence. Santa Fe’s midfield—anchored by Daniel Torres and Alexis Zapata—controls possession effectively (81% and 84% pass accuracy, respectively), which should allow them to dictate rhythm and exploit Cali’s defensive lapses. Deportivo Cali have lost four consecutive matches, suggesting a lack of direction under Alberto Gamero as well as increasing vulnerability away from home.

Both teams tend to adopt a 4-2-3-1 formation in recent games, emphasizing midfield solidity, but Santa Fe’s balance of attacking aggression and defensive resilience stands out. Santa Fe commits an average of 61 fouls in their last five, compared to 53 from Cali, showing an assertive approach that could stifle Deportivo Cali’s transitions. However, their discipline is tested—Santa Fe received 11 yellow cards to Cali’s nine, and both sides are susceptible on set pieces given the volume of fouls conceded. Expect a match with physical battles, especially in the midfield.

• ⚽Total Goals: Under 2.5
• 💥Both Teams To Score: No
• 🎯Total Corners: Over 9.5

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🚨Read our full Santa Fe vs Deportivo Cali stats for more analysis.

Key Stats

• Santa Fe boasts a 42% winrate this year versus Deportivo Cali’s 28%.
• Deportivo Cali have not won a single away match in their last four attempts.
• Santa Fe averages 14.6 total shots per match in their last five—over 20% more than Deportivo Cali’s 12.4.
• Only one red card in Santa Fe’s last five, hinting at controlled aggression despite high foul counts.
• Both teams are most comfortable in 4-2-3-1, but Santa Fe’s midfielders hold a clear advantage in passing accuracy and creation.

Santa Fe vs Deportivo Cali score prediction: 2-0

Given Santa Fe’s home form and their superior attacking threat, a 2-0 result in favor of the hosts looks most probable. Hugo Rodallega will be pivotal in orchestrating chances, while Daniel Torres is expected to provide the midfield steel necessary to support defensive solidity. Deportivo Cali’s recent inability to convert opportunities and clear lack of momentum suggest they will struggle to breach Santa Fe’s disciplined back line.

Pre-game odds and win probability: Santa Fe the favourite

Santa Fe’s odds reflect their marked status as favorites, justified by superior recent performances and stronger squad depth. The shorter price on “Under 2.5 goals” aligns with both sides’ tendency for tight, physical matches without many goals. The “No” for both teams to score is offered at the shortest price, underpinning the expectation that Cali will struggle in attack.

Santa Fe vs Deportivo Cali Over/Under Analysis

• Four of the last five matches involving either team have finished under 2.5 goals.
• Santa Fe has kept a clean sheet in three of their last five home games.
• Deportivo Cali failed to score in three of their last five matches, underscoring their offensive drought.
• Corner kick average per match between these two: 10.6, indicating potential value in over 9.5 corners.

Santa Fe Preview

Santa Fe ended a challenging stretch of form with a resilient 2-1 victory over Junior, a result that showcased both their attacking intent and their capacity for late-game composure. Key forward Hugo Rodallega scored and continues to be the focal point, while midfielder Alexis Zapata’s creativity guided much of the attacking play. Defensively, Emanuel Olivera and Christian Mafla provided the backbone, limiting Junior’s offensive output to half-chances. The match prior, a narrow defeat to Millonarios, underlined lapses in concentration—an area coach Francisco López has reportedly addressed in training.

Deportivo Cali Preview

Deportivo Cali come into the game desperate to reverse their four-match losing streak. Their most recent outing, a 0-1 defeat against Alianza Petrolera, was defined by inefficiency in possession and missed marking assignments at set pieces. Despite flashes of quality from Andrey Estupiñán, the side has lacked cohesion in midfield and been regularly overrun defensively. Coach Alberto Gamero faces mounting pressure to arrest this decline, likely prioritizing defensive discipline and counterattacking opportunities in this away contest.

Our prediction: Who Wins?

As a Tips.GG expert, the main pick for this match is Santa Fe to win. With a win probability of 53 percent according to our dedicated AI engine, this selection reflects both recent form and Santa Fe’s proven quality at home. While Deportivo Cali possesses individuals of note, collective struggles—most notably in attack—render them significant underdogs. Expect Santa Fe to control possession, generate more quality chances, and ultimately secure a professional, hard-fought victory.

How to watch Santa Fe vs Deportivo Cali

When? November 10th, 2025 | 03:30 CEST

Where? Estadio Nemesio Camacho El Campin, Bogotá

How to watch: Check local Colombian sports networks, online streaming platforms, and Primera A’s official streaming partners for live coverage.

Favorite: Santa Fe

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